5-Bromonaphthalene-1-carboxylic acid → 5-(Pyridin-4-yl)-1-naphthoic Acid

HRID 1275005

Reaction equation

HRID 1275005 reaction equation
[N:1]1[CH:6]=[CH:5][C:4](B(O)O)=[CH:3][CH:2]=1.Br[C:11]1[CH:20]=[CH:19][CH:18]=[C:17]2[C:12]=1[CH:13]=[CH:14][CH:15]=[C:16]2[C:21]([OH:23])=[O:22]>>[N:1]1[CH:6]=[CH:5][C:4]([C:11]2[CH:20]=[CH:19][CH:18]=[C:17]3[C:12]=2[CH:13]=[CH:14][CH:15]=[C:16]3[C:21]([OH:23])=[O:22])=[CH:3][CH:2]=1

Participants

3

Reactant 2

HCID 6976055-Bromonaphthalene-1-carboxylic acidHCID 2734379(Pyridin-4-yl)boronic acid

Product 1

HCID 221189105-(Pyridin-4-yl)-1-naphthoic Acid

Procedure

The title compound was prepared from 4-pyridylboronic acid and 5-bromo-1- naphthoic acid (J. Chem. Soc., 1950, 991) using a similar procedure to Example 4, obtained as a white solid (55%).

Sources & evidence

ORD record
ord-f88071939c1448f39ba56d4832888c3d
Source dataset
uspto-grants-2000_12
Patent number
US06159979

Linked notes

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