1-Iodohexane → HCID 86584054, compound

Reaction equation

[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH:21]=[CH:22][C:23]=1[O:24][CH3:25])[C:6]([C:8]1[N:12]([CH3:13])[C:11]([CH2:14][C:15]([O:17]CC)=[O:16])=[CH:10][C:9]=1[CH3:20])=[O:7].C(I)CCCCC>>[CH2:14]([C:11]1[N:12]([CH3:13])[C:8]([C:6](=[O:7])[C:5]2[CH:21]=[CH:22][C:23]([O:24][CH3:25])=[C:3]([O:2][CH3:1])[CH:4]=2)=[C:9]([CH3:20])[CH:10]=1)[CH3:15].[CH2:11]([CH2:14][C:15]([O-:17])=[O:16])[CH2:10][CH2:9][CH2:8][CH2:6][CH3:5]

Participants

Reactant 2

HCID 125271-Iodohexane

HCID 18424209HCID 18424209, compound

Product 1

HCID 86584054HCID 86584054, compound

Procedure

The alkylation procedure of Example 77A is performed upon ethyl 5-(3',4'-dimethoxybenzoyl)-1,4-dimethylpyrrole-2-acetate (from Example 90), using an equivalent quantity of n-hexyl iodide instead of methyl iodide used in Example 77A to yield ethyl 5-(3',4'-dimethoxybenzoyl)-1,4-dimethylpyrrole-2-(α-n-hexyl)-acetate.

Sources & evidence

ORD record: ord-a824b00b8cbf4031bb7a26eea6afa4db
Source dataset: uspto-grants-2000_12
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06160003

Reaction notes

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