Phosgene → 2-Chloro-6-iodo-3-propyl-quinazolin-4-one
Reaction equation
[I:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[NH:8][C:7](=S)[N:6]([CH2:13][CH2:14][CH3:15])[C:5]2=[O:16].C(Cl)([Cl:19])=O>>[Cl:19][C:7]1[N:6]([CH2:13][CH2:14][CH3:15])[C:5](=[O:16])[C:4]2[C:9](=[CH:10][CH:11]=[C:2]([I:1])[CH:3]=2)[N:8]=1Participants
3
Procedure
2,3-dihydro-6-iodo-3-propyl-2-thioxo-4(1H)-quinazolinone is reacted with phosgene to give 2-chloro-6-iodo-3-propyl-4(3H)-quinazolinone ; and
Sources & evidence
- ORD record
- ord-f04be63b61e24051b16d00493f43d62d
- Source dataset
- uspto-grants-2000_12
- Patent number
- US06166208
Reaction notes
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