HuagongsheHuagongshe Chemistry Print Report · For research reference only
Cyclopropylamine → HCID 178418304, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Cyclopropylamine | HCID 69828 | — |
| Reactant | Ethyl 2-(2,4,5-trifluoro-6-methylbenzoyl)-3-ethoxyacrylate | HCID 54242925 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | HCID 178418304 | HCID 178418304 | — |
Reaction Steps
Ethyl 2-(2-methyl-3,4,6-trifluorobenzoyl)-3-ethoxyacrylate (3.5 g) is dissolved in ethanol (25 ml) and thereto cyclopropylamine (0.84 ml) is added dropwise under ice-cooling. After stirring at room temperature for 30 minutes, the mixture is concentrated and the residue is purified with column chromatography (silica-gel, dichloromethane: n-hexane =1: 1) to give ethyl 2-(2-methyl-3,4,6-trifluorobenzoyl)-3-cyclopropylaminoacrylate (2.7 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05723648 |
| Source dataset | uspto-grants-1998_03 |
| ORD ID | ord-a6bc9092d4d54296b6f4a8701204549f |
| Source note | uspto-grants-1998_03 |