Bromine → 4-(Bromomethyl)-2-fluoro-1,1′-biphenyl
Reaction equation
[Br:1]Br.[F:3][C:4]1[CH:9]=[C:8]([CH3:10])[CH:7]=[CH:6][C:5]=1[C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1>C(Cl)(Cl)(Cl)Cl>[F:3][C:4]1[CH:9]=[C:8]([CH2:10][Br:1])[CH:7]=[CH:6][C:5]=1[C:11]1[CH:12]=[CH:13][CH:14]=[CH:15][CH:16]=1Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
In a similar experiment 0.8 equivalent of Br2 was added dropwise to a refluxing solution of 2-fluoro-4-methylbiphenyl (2) and CCl4. NMR analysis showed the ratio of starting material:monobromide:dibromide to be 31:61:8.
Sources & evidence
- ORD record
- ord-0b9b4d9e1f7d46c2aacde62f633cca60
- Source dataset
- uspto-grants-1981_07
- Patent number
- US04278516
Reaction notes
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