Ethyl butyrate → Ethyl 2-formylbutanoate

HRID 1277739Notes

Reaction equation

[C:1]([O:6][CH2:7][CH3:8])(=[O:5])[CH2:2][CH2:3][CH3:4].[CH3:9][O-:10].[Na+]>>[CH2:7]([O:6][C:1](=[O:5])[CH:2]([CH:9]=[O:10])[CH2:3][CH3:4])[CH3:8]

Participants

Reactant 2

HCID 7762Ethyl butyrate

HCID 10942334Sodium Methoxide

Product 1

HCID 289299Ethyl 2-formylbutanoateYield 85%

Procedure

1200 g Ethyl butyrate was reacted with 130 g 85% sodium methylate substantially as in Example 1 to produce 245 g 2-formylbutyric acid ethyl ester (85% yield) boiling at 60°-64° C./14 torr. n20D =1.4300.

Sources & evidence

ORD record: ord-181df39d622c4e2b8777a894277e77d5
Source dataset: uspto-grants-1981_07
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04278808

Reaction notes

Loading…