3-Dimethylamino-1-thien-3-ylpropen-1-one → Ethyl 7-(3-thienyl)pyrazolo[1,5-a]pyrimidine-3-carboxylate

HRID 1278201

Reaction equation

HRID 1278201 reaction equation
[NH2:1][C:2]1[C:6]([C:7]([O:9][CH2:10][CH3:11])=[O:8])=[CH:5][NH:4][N:3]=1.CN(C)[CH:14]=[CH:15][C:16]([C:18]1[CH:22]=[CH:21][S:20][CH:19]=1)=O>C(O)(=O)C>[CH2:10]([O:9][C:7]([C:6]1[CH:5]=[N:4][N:3]2[C:16]([C:18]3[CH:22]=[CH:21][S:20][CH:19]=3)=[CH:15][CH:14]=[N:1][C:2]=12)=[O:8])[CH3:11]

Participants

4

Reactant 2

HCID 5964663-Dimethylamino-1-thien-3-ylpropen-1-oneHCID 178469928HCID 178469928, compound

Product 1

HCID 11818144Ethyl 7-(3-thienyl)pyrazolo[1,5-a]pyrimidine-3-carboxylate

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

As for Example 2, 3.10 g. of 3-amino-4-carboethoxypyrazole is heated at reflux temperature for 10 hours with 3.62 g. of 3-dimethylamino-1-(3-thienyl)-2-propen-1-one in 25 ml. of glacial acetic acid to give 4.40 g. of the product of the example as tan crystals, m.p. 129°-130° C.

Workup

  1. temperatureat reflux temperature for 10 hours with 3.62 g

Sources & evidence

ORD record
ord-a768b290b1274cb8910d94774ff74d5f
Source dataset
uspto-grants-1981_07
Patent number
US04281000

Linked notes

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