Hydroxide → 1-Phenyl-2-propanol

HRID 128001

Reaction equation

HRID 128001 reaction equation
O.[OH-].[C:3]1([CH2:9][C:10](=[O:12])[CH3:11])[CH:8]=[CH:7][CH:6]=[CH:5][CH:4]=1>C(O)C>[C:3]1([CH2:9][CH:10]([OH:12])[CH3:11])[CH:8]=[CH:7][CH:6]=[CH:5][CH:4]=1

Participants

5

Reactant 3

HCID 961HydroxideHCID 962WaterHCID 7678Phenylacetone

Product 1

HCID 941851-Phenyl-2-propanol

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Conditions

Temperature
80 °C

Procedure

In a 4 liter three-necked flask fitted with a mechanical stirrer and a reflux condenser, were placed 1500 ml of water, 150 g ofsodium hydroxide (pellets), 190 ml of ethanol and 180 g of phenylacetone. The mixture was stirred and heated to 80° C., and 150 g of Raney alloy was added very cautiously by small amounts over about 1 hour. During the addition, heating was discontinued and the temperature was maintained at 85°-87° C.

Workup

  1. customIn a 4 liter three-necked flask fitted with a mechanical stirrer and a reflux condenser
  2. addition150 g of Raney alloy was added very cautiously by small amounts over about 1 hour
  3. additionDuring the addition
  4. temperatureheating
  5. temperaturethe temperature was maintained at 85°-87° C.

Sources & evidence

ORD record
ord-6fb44f952434407bb6a64e1190cd6c08
Source dataset
uspto-grants-1981_03
Patent number
US04258120

Linked notes

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