Ethanol → 2-Methoxybenzoylacetonitrile

HRID 128166

Reaction equation

HRID 128166 reaction equation
Br[CH2:2][C:3]([C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][C:6]=1[O:11][CH3:12])=[O:4].C(O)C.[C-:16]#[N:17].[Na+]>O>[CH3:12][O:11][C:6]1[CH:7]=[CH:8][CH:9]=[CH:10][C:5]=1[C:3]([CH2:2][C:16]#[N:17])=[O:4]

Participants

5

Reactant 3

HCID 702EthanolHCID 8929Sodium CyanideHCID 123440Bromomethyl 2-methoxyphenyl ketone

Product 1

HCID 49627502-Methoxybenzoylacetonitrile

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

A 10.0 g. portion of α-bromo-o-methoxyacetophenone is suspended in 50 ml. of ethanol. A solution of 6.4 g. of sodium cyanide in 30 ml. of water is added as described in Example 8. Following the procedure of Example 8, there is obtained o-methoxybenzoylacetonitrile.

Sources & evidence

ORD record
ord-438d4666971e412abba4fa46585dfb7f
Source dataset
uspto-grants-1981_03
Patent number
US04259256

Linked notes

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