Butylamine → 2-Benzoyl-3-butylaminocrotononitrile
Reaction equation
[C:1](/[C:9](=[C:12](/OC)\[CH3:13])/[C:10]#[N:11])(=[O:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH2:16]([NH2:20])[CH2:17][CH2:18][CH3:19]>>[C:1](/[C:9](=[C:12](/[NH:20][CH2:16][CH2:17][CH2:18][CH3:19])\[CH3:13])/[C:10]#[N:11])(=[O:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1Participants
3
Procedure
A sample of 2.5 g. of 2-benzoyl-3-methoxycrotononitrile is dissolved in 10 ml. of n-butylamine. The solution is sealed in a stainless steel bomb and heated on a steam bath overnight. The bomb is then opened and the solvent evaporated under reduced pressure. A greenish oil is obtained which is distilled on a Kugelrohr apparatus at 200° C./0.1 mm. to obtain the yellow oily product.
Workup
- temperatureheated on a steam bath overnight
- customthe solvent evaporated under reduced pressure
- customA greenish oil is obtained which
- distillationis distilled on a Kugelrohr apparatus at 200° C./0.1 mm
- customto obtain the yellow oily product