5-Chloro-2-methylphenyl isothiocyanate → 1-(5-Chloro-2-methyl-phenyl)-3-(2-methyl-benzothiazol-5-yl)-thiourea

Participants

Reaction Steps

Prepared using Method A from 4.5 g (24.5 mmol) of 5-chloro-2-methyl-phenyl isothiocyanate and 4.02 g (24.5 mmol) of 5-amino-2-methylbenzothiazole to give 6.0 g of crude material. Soxhlet extraction with EtOAc gave 2.5 g of pure title compound as a tan solid (29% yield, m.p. 173-174° C. ).

Provenance & Evidence