HCID 85848304, compound → HCID 85848305, compound
Reaction equation
[CH2:1]([N:3]1[CH2:10][CH:9]2[CH:5]([CH2:6][CH2:7][CH2:8]2)[C:4]1=[CH:11][N+:12]([O-])=O)[CH3:2]>[Ni].CO>[CH2:1]([N:3]1[CH2:10][CH:9]2[CH:5]([CH2:6][CH2:7][CH2:8]2)[CH:4]1[CH2:11][NH2:12])[CH3:2]Participants
4
Reactant 1
Product 1
Reagents, catalysts & solvents 2
Procedure
54 parts of N-ethyl-2-nitromethylene-3-azabicyclo (3,3,0) octane, in solution in 500 parts of anhydrous methanol were reduced in presence of 20 parts of Raney Nickel at 5 kg/m2 pressure. After filtration and washing of the catalyst by methanol, the filtrate was evaporated under vacuo then distilled. There were obtained 30 parts of N-ethyl-2-aminomethyl-3-azabicyclo (3,3,0) octane, B.P./0.25-0.30 mm Hg : 88°-90° C. This reduction can be easily carried out with lithium aluminium hydride too.
Workup
- filtrationAfter filtration
- washwashing of the catalyst by methanol
- customthe filtrate was evaporated under vacuo
- distillationthen distilled
Sources & evidence
- ORD record
- ord-5449d0fba33048aaa7e3423cc762b3c4
- Source dataset
- uspto-grants-1976_08
- Patent number
- US03972994
Reaction notes
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