Nitric Acid → HCID 86733824, compound
Reaction equation
[N+]([O-])(O)=[O:2].[OH:5][C:6]1[C:15]2[C:10](=[CH:11][CH:12]=[CH:13][C:14]=2OC)[O:9][C:8](=[O:18])[CH:7]=1>C(Cl)(Cl)Cl>[OH2:2].[OH:5][C:6]1[C:15]2[C:10](=[CH:11][C:12]([OH:2])=[CH:13][CH:14]=2)[O:9][C:8](=[O:18])[CH:7]=1Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
Fuming nitric acid (10 ml) was added to a stirred solution of 4-hydroxy-5-methoxycoumarin (m.p. 154.5°-156°; 1.63g) in chloroform (100 ml) at room temperature over 1 hour. After a further hour, the solvent was removed in vacuo and 6N hydrochloric acid (35 ml) added to the residue. Filtration gave the product, m.p. 175°-177.5°(d), (C10H7NO6 requires C, 50.64; H, 2.97; N, 5.91. Found: C, 50.54; H, 2.97; N, 5.63).
Workup
- waitAfter a further hour
- customthe solvent was removed in vacuo and 6N hydrochloric acid (35 ml)
- additionadded to the residue
- filtrationFiltration
Sources & evidence
- ORD record
- ord-0ed3fee058ba4520b12eb9e8c97182df
- Source dataset
- uspto-grants-1976_08
- Patent number
- US03974289
Reaction notes
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