HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Hydroxypyrrolidine → 5-(3-Hydroxy-pyrrolidin-1-yl)-1-methyl-1h-pyrazole-4-carboxylic acid adamantan-2-ylamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Hydroxypyrrolidine | HCID 98210 | — |
| Reactant | 5-chloro-1-methyl-1H-pyrazole-4-carboxylic acid adamantan-2-ylamide | HCID 25013543 | — |
| Product | 5-(3-Hydroxy-pyrrolidin-1-yl)-1-methyl-1h-pyrazole-4-carboxylic acid adamantan-2-ylamide | HCID 25014039 | — |
Reaction Steps
Heating a mixture of 5-chloro-1-methyl-1H-pyrazole-4-carboxylic acid adamantan-2-ylamide (Example 5, 88 mg; 0.30 mmol) and DL-3-pyrrolidinol (0.25 mL; 3.0 mmol) under microwave irradiation according to the procedure described for Example 14 provided after purification by reverse phase HPLC, 5-(3-hydroxy-pyrrolidin-1-yl)-1-methyl-1H-pyrazole-4-carboxylic acid adamantan-2-ylamide (68 mg, 66%) as an off-white powder. ES-HRMS m/e calcd for C19H29N4O2 (M+H+) 345.2285, found 345.2281.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07728029B2 |
| Source dataset | uspto-grants-2010_06 |
| ORD ID | ord-72d140f22a01450bba8fbc9a3a48a46d |
| Source note | uspto-grants-2010_06 |