Reaction equation
[S:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[CH2:6][O:7][CH2:8][C:9]([NH:11][NH2:12])=[O:10].[Cl:13][C:14]1[CH:31]=[CH:30][C:17]2[O:18][C:19]3[CH:29]=[CH:28][CH:27]=[CH:26][C:20]=3[CH2:21][N:22]([C:23](Cl)=[O:24])[C:16]=2[CH:15]=1>>[S:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[CH2:6][O:7][CH2:8][C:9]([NH:11][NH:12][C:23]([N:22]1[CH2:21][C:20]2[CH:26]=[CH:27][CH:28]=[CH:29][C:19]=2[O:18][C:17]2[CH:30]=[CH:31][C:14]([Cl:13])=[CH:15][C:16]1=2)=[O:24])=[O:10]Participants
3
Procedure
8-chlorodibenz[b,f][1,41oxazepine-10(11H)-carboxylic acid, 2-[(2-thienylmethoxy)acetyl]hydrazide (21) was prepared in the manner described in Example 6 from 1 mmol of 2-(2-thienylmethoxy)acetic acid, hydrazide (20), prepared as described above in Example 20, and 1.0 mmol of 8-chlorodibenz[b,f][1,41oxazepine-10(11H)-carbonyl chloride (2), prepared as described above in Example 2, to yield 0.28 g (64%) of product. Analysis calculated for C21H18N3O4SCl (M.W. 443.91): C, 56.82; H, 4.09; N, 9.47. Found: C, 56.55; H, 4.08; N, 9.28.
Workup
- customprepared
- customprepared
Sources & evidence
- ORD record
- ord-6bcd3502a0774c38bf0b2f5fb4b1f3a2
- Source dataset
- uspto-grants-1995_11
- Patent number
- US05464830
Linked notes
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