Methyl 3-[(2-thienylmethyl)thio]propanoate → 3-[(2-Thienylmethyl)thio]propanoic acid, hydrazide
Reaction equation
O1[CH:5]=[CH:4][CH:3]=[C:2]1[CH2:6][S:7][CH2:8][CH2:9][C:10]([NH:12][NH2:13])=[O:11].[S:14]1C=CC=C1CSCCC(OC)=O>>[S:14]1[CH:5]=[CH:4][CH:3]=[C:2]1[CH2:6][S:7][CH2:8][CH2:9][C:10]([NH:12][NH2:13])=[O:11]Participants
3
Procedure
3-[(2-thienylmethyl)thio]propanoic acid, hydrazide (56) was prepared in the manner that 3-[(2-furanylmethyl)thio]propanoic acid, hydrazide (12) was prepared (Example 12) on a 23 mmol scale from methyl 3-[(2-thienylmethyl)thio]propanoate (55). After the solvent was removed under vacuum, 2.77 g (69%) of the product, which was a water white viscous liquid, was recovered and was used immediately in the manner described in Example 57, below.
Workup
- customAfter the solvent was removed under vacuum, 2.77 g (69%) of the product, which
- customwas recovered
Sources & evidence
- ORD record
- ord-3dfd411196c04df29cc61bdc5e714135
- Source dataset
- uspto-grants-1995_11
- Patent number
- US05464830
Reaction notes
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