2-(Methylamino)ethanol → N-(beta-hydroxyethyl)-N-methyl-N'-(2-trifluoromethyl-1,3,4-thiadiazol-5-yl)urea
Reaction equation
[F:1][C:2]([F:12])([F:11])[C:3]1[S:4][C:5]([N:8]=[C:9]=[O:10])=[N:6][N:7]=1.[CH3:13][NH:14][CH2:15][CH2:16][OH:17]>C1C=CC=CC=1>[OH:17][CH2:16][CH2:15][N:14]([CH3:13])[C:9]([NH:8][C:5]1[S:4][C:3]([C:2]([F:11])([F:1])[F:12])=[N:7][N:6]=1)=[O:10]Participants
4
Procedure
2-Trifluoromethyl-1,3,4-thiadiazol-5-yl isocyanate dimer (8 grams), N-methyl-N-β-hydroxyethylamine (3.1 grams) and benzene (40 ml) were charged into a glass reaction vessel equipped with a mechanical stirrer, reflux condenser and thermometer. The reaction mixture was heated at reflux, with stirring for a period of about 10 minutes. After this time the reaction mixture was stripped of solvent under reduced pressure to yield the desired product N-(β-hydroxyethyl)-N-methyl-N'-(2-trifluoromethyl-1,3,4-thiadiazol-5-yl)urea as an oily residue.