Ammonia → 6-Amino-4-butylamino-2-methyl-5-nitronicotinic acid ethyl ester
Reaction equation
[CH2:1]([NH:5][C:6]1[C:11]([N+:12]([O-:14])=[O:13])=[C:10](Cl)[N:9]=[C:8]([CH3:16])[C:7]=1[C:17]([O:19][CH2:20][CH3:21])=[O:18])[CH2:2][CH2:3][CH3:4].[NH3:22]>CO>[NH2:22][C:10]1[N:9]=[C:8]([CH3:16])[C:7]([C:17]([O:19][CH2:20][CH3:21])=[O:18])=[C:6]([NH:5][CH2:1][CH2:2][CH2:3][CH3:4])[C:11]=1[N+:12]([O-:14])=[O:13]Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
177.9 g. of 4-butylamino-6-chloro-2-methyl-5-nitropyridine-3-carboxylic acid, ethyl ester (0.5 Mol.) dissolved in 500 ml. of methanol are heated with 300 ml. of aqueous ammonia (30%) in an autoclave at about 60° for 10 hours. After this time, the solvent is distilled off and the residual 6-amino-4-butylamino-2-methyl-5-nitropyridine-3-carboxylic acid, ethyl ester is recrystallized from methanol, yield 135 g.; m.p. 98°-99°.