6-Methyl-5-nitro-2-(pyridin-2-yl)-1,3-benzoxazole → 6-Methyl-2-(pyridin-2-yl)-1,3-benzoxazol-5-amine
Reaction equation
[CH3:1][C:2]1[C:16]([N+:17]([O-])=O)=[CH:15][C:5]2[N:6]=[C:7]([C:9]3[CH:14]=[CH:13][CH:12]=[CH:11][N:10]=3)[O:8][C:4]=2[CH:3]=1>C(O)C.[Pt]=O>[NH2:17][C:16]1[C:2]([CH3:1])=[CH:3][C:4]2[O:8][C:7]([C:9]3[CH:14]=[CH:13][CH:12]=[CH:11][N:10]=3)=[N:6][C:5]=2[CH:15]=1Participants
4
Reactant 1
Product 1
Reagents, catalysts & solvents 2
Procedure
A suspension of 6-methyl-5-nitro-2-(2-pyridinyl)benzoxazole (10.0 g, 0.044 mole) and platinum oxide (1.0 g) in 150 ml of ethanol is hydrogenated over a period of 2 hours. The catalyst is separated by filtration and the ethanol removed under vacuum yielding 8.7 g of the title compound.
Workup
- customThe catalyst is separated by filtration
- customthe ethanol removed under vacuum
Sources & evidence
- ORD record
- ord-40965b7c61254712aa62f8b5df0e32d0
- Source dataset
- uspto-grants-1976_10
- Patent number
- US03985755
Reaction notes
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