HuagongsheHuagongshe Chemistry Print Report · For research reference only
Phenylacetylene → 4-(Phenylethynyl)benzaldehyde
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Phenylacetylene | HCID 10821 | — |
| Reactant | 4-Bromobenzaldehyde | HCID 70741 | — |
| Catalyst | Palladium(2+) acetate--triphenylphosphane (1/2/2) | HCID 84538 | — |
| Product | 4-(Phenylethynyl)benzaldehyde | HCID 609908 | 70% |
Reaction Steps
By the method of example 53(A), but using bis(triphenylphosphine)palladium(II) acetate as catalyst (3 mol %), phenylacetylene and 4-bromobenzaldehyde are coupled to give 4-(2-phenylethynyl)benzaldehyde in 70% yield after distillation. By the methods of example 1, this is converted into the title compound, obtained as a colorless solid, mp 190°-191° after recrystallization from hexane-ethyl acetate.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05464865 |
| Source dataset | uspto-grants-1995_11 |
| ORD ID | ord-843acba50177435e8a47409e0d2ace33 |
| Source note | uspto-grants-1995_11 |