Acetic Anhydride → HCID 18922226, compound
Reaction equation
[NH2:1][C:2]1[N:6]=[C:5]([NH2:7])[N:4]([C:8]([NH:10][CH3:11])=[S:9])[N:3]=1.[C:12](OC(=O)C)(=[O:14])[CH3:13]>N1C=CC=CC=1>[C:12]([NH:1][C:2]1[N:6]=[C:5]([NH2:7])[N:4]([C:8]([NH:10][CH3:11])=[S:9])[N:3]=1)(=[O:14])[CH3:13]Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
To the compound (3.00 g) obtained in Example 31 and pyridine (25 ml) was gradually added dropwise acetic anhydride (2.1 ml) under ice-cooling. The mixture was stirred at 0° C.-room temperature for 66 hours and the resulting crystals were collected by filtration. The crystals were washed with hexane-ethyl acetate and dried to give 2.98 g of white powdery crystals (yield 80%).
Workup
- temperaturecooling
- filtrationthe resulting crystals were collected by filtration
- washThe crystals were washed with hexane-ethyl acetate
- customdried
Sources & evidence
- ORD record
- ord-4362d6ef743841ef9950f9d4e6c0ab48
- Source dataset
- uspto-grants-1998_05
- Patent number
- US05750545
Reaction notes
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