Methanol, 1,1-diethoxy-, 1-acetate → HCID 86752545, compound

Reaction equation

[NH2:1][C:2]1[N:6]=[C:5]([NH2:7])[N:4]([C:8]([NH:10][CH3:11])=[S:9])[N:3]=1.[C:12]([O:15][CH:16](OCC)OCC)(=O)[CH3:13]>>[NH2:7][C:5]1[N:4]([C:8]([NH:10][CH3:11])=[S:9])[N:3]=[C:2]([N:1]=[CH:16][O:15][CH2:12][CH3:13])[N:6]=1

Participants

Reactant 2

HCID 84166Methanol, 1,1-diethoxy-, 1-acetate

HCID 10725863HCID 10725863, compound

Product 1

HCID 86752545HCID 86752545, compoundYield 73%

Procedure

A solution of the compound (500 mg) obtained in Example 31 and diethoxymethyl acetate (7 ml) was stirred at room temperature. After stirring for 1 hour, the resulting crystals were collected by filtration to give 480 mg of a white powdery solid (yield 73%).

Workup

filtrationthe resulting crystals were collected by filtration

Sources & evidence

ORD record: ord-05f19ef343e343f58909148af11092a2
Source dataset: uspto-grants-1998_05
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05750545

Reaction notes

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