Methanol, 1,1-diethoxy-, 1-acetate → 6-Methyl[1,2,4]triazolo[1,5-a][1,3,5]triazine-7(6h)-thione

HRID 1289796Notes

Reaction equation

HRID 1289796 reaction equation
[NH2:1][C:2]1[N:6]([C:7]([NH:9][CH3:10])=[S:8])[N:5]=[CH:4][N:3]=1.[C:11](OC(OCC)OCC)(=O)C>>[CH3:10][N:9]1[C:7](=[S:8])[N:6]2[N:5]=[CH:4][N:3]=[C:2]2[N:1]=[CH:11]1

Participants

3

Reactant 2

HCID 84166Methanol, 1,1-diethoxy-, 1-acetateHCID 32648395-amino-N-methyl-1,2,4-triazole-1-carbothioamide

Product 1

HCID 2866546-Methyl[1,2,4]triazolo[1,5-a][1,3,5]triazine-7(6h)-thioneYield 88%

Procedure

The synthesis method of Example 55 was applied. The compound (1.49 g) obtained in Example 29 and diethoxymethyl acetate (12 ml) were used as reagents. The mixture was reacted at 75° C. for 2 hours to give 1.39 g of white crystals (yield 88%). The crystals were subjected to recrystallization from acetone to give white crystals.

Workup

  1. customThe synthesis method of Example 55
  2. customThe mixture was reacted at 75° C. for 2 hours

Sources & evidence

ORD record
ord-4146b97b44e04cf2987c623a3440ef5f
Source dataset
uspto-grants-1998_05
Patent number
US05750545

Reaction notes

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