Methanol, 1,1-diethoxy-, 1-acetate → HCID 10684276, compound

Reaction equation

[NH2:1][C:2]1[N:6]([C:7]([NH:9][CH3:10])=[S:8])[N:5]=[C:4]([NH:11][C:12]([C:14]([O:16][CH2:17][CH3:18])=[O:15])=[O:13])[N:3]=1.[C:19](OC(OCC)OCC)(=O)C>>[C:12]([NH:11][C:4]1[N:3]=[C:2]2[N:1]=[CH:10][N:9]([CH3:19])[C:7](=[S:8])[N:6]2[N:5]=1)([C:14]([O:16][CH2:17][CH3:18])=[O:15])=[O:13]

Participants

Reactant 2

HCID 84166Methanol, 1,1-diethoxy-, 1-acetate

HCID 86752547HCID 86752547, compound

Product 1

HCID 10684276HCID 10684276, compoundYield 78%

Procedure

The synthesis method of Example 55 was applied. The compound (551 mg) obtained in Example 35 and diethoxymethyl acetate (8 ml) were used as reagents. The mixture was reacted at 90° C. for 2 hours to give 442 mg of white powdery crystals (yield 78%).

Workup

customThe synthesis method of Example 55
customThe mixture was reacted at 90° C. for 2 hours

Sources & evidence

ORD record: ord-584e223ed1234dba9eb1c5f259aab9df
Source dataset: uspto-grants-1998_05
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05750545

Reaction notes

Loading…