HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1290159Generated: October 25, 2026
Potassium Carbonate → 8-[2-(2,6-Dichlorophenyl)ethyloxy]-2-methylimidazo[1,2-a]pyridine
https://huagongshe.com/reaction/1290159
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 2-Methylimidazo[1,2-a]pyridin-8-ol | HCID 820953 | — |
| Reactant | 2-(2,6-Dichlorophenyl)ethyl methanesulfonate | HCID 15565622 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 8-[2-(2,6-Dichlorophenyl)ethyloxy]-2-methylimidazo[1,2-a]pyridine | HCID 18923336 | 23.4% |
Reaction Steps
A mixture of 8-hydroxy-2-methylimidazo[1,2-a]pyridine (296 mg), 1,3-dichloro-2-(2-mesyloxyethyl)benzene (645 mg) and potassium carbonate (828 mg) in N,N-dimethylformamide (12 ml) was stirred for 6 hours at 70° C. The mixture was treated according to a similar manner to that of Preparation 16 to give 8-[2-(2,6-dichlorophenyl)ethyloxy]-2-methylimidazo[1,2-a]pyridine (150 mg).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US05750699 |
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| Source dataset | uspto-grants-1998_05 |
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| ORD ID | ord-e000f68925e64e869fe194b41ff6db91 |
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| Source note | uspto-grants-1998_05 |
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