HCID 18919774, compound → HCID 18919904, compound
Reaction equation
[Cl:1][C:2]1[CH:24]=[CH:23][C:5]([C:6]([O:8][CH:9]2[CH2:14][CH2:13][N:12]([CH2:15][C:16]3[CH:21]=[CH:20][C:19]([Br:22])=[CH:18][CH:17]=3)[CH2:11][CH2:10]2)=[O:7])=[CH:4][CH:3]=1>CCOCC>[ClH:1].[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([C:6]([O:8][CH:9]2[CH2:10][CH2:11][N:12]([CH2:15][C:16]3[CH:17]=[CH:18][C:19]([Br:22])=[CH:20][CH:21]=3)[CH2:13][CH2:14]2)=[O:7])=[CH:23][CH:24]=1Participants
3
Reactant 1
Product 1
Reagents, catalysts & solvents 1
Procedure
0.204 g (0.00055 mol) of 1-(4-bromo-benzyl)-piperidin-4-yl 4-chloro-benzoate was dissolved in 15 ml of ether, filtered, diluted with 0.75 ml of methanol and treated with 5ml of 1N ethereal HCI. The separated precipitate was filtered off and dried. 0.188 g (83.6%) of 1-(4-bromo-benzyl)-piperidin-4-yl 4-chloro-benzoate hydrochloride (1:1) was obtained as white crystals; m.p. 240°-242°.
Workup
- filtrationfiltered
- additiondiluted with 0.75 ml of methanol