HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-Bromo-4-iodobenzene → 2-{4-[3-(4-Bromo-phenyl)-prop-2-ynyloxy]-phenoxymethyl}-pyrrolidine-1-carboxylic acid tert-butyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-Bromo-4-iodobenzene | HCID 11522 | — |
| Reactant | Pyrrolidine | HCID 31268 | — |
| Reactant | 2-(4-Prop-2-ynyloxy-phenoxymethyl)-pyrrolidine-1-carboxylic acid tert-butyl ester | HCID 86619656 | — |
| Catalyst | Palladium Chloride | HCID 24290 | — |
| Solvent | Water | HCID 962 | — |
| Product | 2-{4-[3-(4-Bromo-phenyl)-prop-2-ynyloxy]-phenoxymethyl}-pyrrolidine-1-carboxylic acid tert-butyl ester | HCID 68429658 | 33.8% |
Reaction Steps
General procedure A was followed using the product from step 3 Example 1 (266 mg, 0.803 mmol), p-bromo iodobenzene (156.5 mg, 0.669 mmol), PdCl2 (2.5 mg, 0.014 mmol), pyrrolidine (0.277 mL, 3.34 mmol), water (0.844 mL) to give the title compound (110 mg, 33.8%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07728032B2 |
| Source dataset | uspto-grants-2010_06 |
| ORD ID | ord-f40eca44ce424484a1a2bde3e1058889 |
| Source note | uspto-grants-2010_06 |