(S)-Methyl 4-(1-aminoethyl)benzoate hydrochloride → HCID 57572327, compound
Reaction equation
[F:1][C:2]1[CH:3]=[N:4][C:5]([O:11][C:12]2[CH:17]=[CH:16][CH:15]=[C:14]([F:18])[CH:13]=2)=[C:6]([CH:10]=1)[C:7]([OH:9])=O.Cl.[NH2:20][C@H:21]([C:23]1[CH:32]=[CH:31][C:26]([C:27]([O:29][CH3:30])=[O:28])=[CH:25][CH:24]=1)[CH3:22]>>[F:1][C:2]1[CH:10]=[C:6]([C:7]([NH:20][C@H:21]([C:23]2[CH:32]=[CH:31][C:26]([C:27]([O:29][CH3:30])=[O:28])=[CH:25][CH:24]=2)[CH3:22])=[O:9])[C:5]([O:11][C:12]2[CH:17]=[CH:16][CH:15]=[C:14]([F:18])[CH:13]=2)=[N:4][CH:3]=1Participants
3
Procedure
The title compound was prepared according to the procedure described in step 3 of Example 1 from 5-fluoro-2-(3-fluorophenoxy)nicotinic acid (step 1) and methyl 4-[(1S)-1-aminoethyl]benzoate hydrochloride (step 3 of Example 5): 1H-NMR (CDCl3) δ 8.33 (1H, dd, J=8.2, 3.1 Hz), 8.12–7.98 (4H, m), 7.47–7.38 (3H, m), 7.05–6.89 (3H, m), 5.36 (1H, m), 3.90 (3H, s), 1.60 (3H, d, J=6.9 Hz).
Sources & evidence
- ORD record
- ord-e43c4b3c43d54324a604e6d1fec10138
- Source dataset
- uspto-grants-2007_07