M-Cresol → tert-Butyl 4-[(1S)-1-({[5-chloro-2-(3-methylphenoxy)pyridin-3-yl]carbonyl}amino)ethyl]benzoate

HRID 1293282

Reaction equation

HRID 1293282 reaction equation
Cl[C:2]1[C:7]([C:8]([NH:10][C@H:11]([C:13]2[CH:25]=[CH:24][C:16]([C:17]([O:19][C:20]([CH3:23])([CH3:22])[CH3:21])=[O:18])=[CH:15][CH:14]=2)[CH3:12])=[O:9])=[CH:6][C:5]([Cl:26])=[CH:4][N:3]=1.[CH:27]1[C:32]([OH:33])=[CH:31][CH:30]=[CH:29][C:28]=1[CH3:34]>>[Cl:26][C:5]1[CH:6]=[C:7]([C:8]([NH:10][C@H:11]([C:13]2[CH:25]=[CH:24][C:16]([C:17]([O:19][C:20]([CH3:23])([CH3:22])[CH3:21])=[O:18])=[CH:15][CH:14]=2)[CH3:12])=[O:9])[C:2]([O:33][C:32]2[CH:31]=[CH:30][CH:29]=[C:28]([CH3:34])[CH:27]=2)=[N:3][CH:4]=1

Participants

3

Reactant 2

HCID 342M-CresolHCID 57572256tert-butyl 4-((1S)-1-{[(2,5-dichloropyridin-3-yl)carbonyl]amino}ethyl)benzoate

Product 1

HCID 69419528tert-Butyl 4-[(1S)-1-({[5-chloro-2-(3-methylphenoxy)pyridin-3-yl]carbonyl}amino)ethyl]benzoate

Procedure

The title compound was prepared according to the procedure described in step 2 of Example 45 from tert-butyl 4-((1S)-1-{[(2,5-dichloropyridin-3-yl)carbonyl]amino}ethyl)benzoate (step 1 of Example 45) and m-cresol: MS (ESI) m/z 467 (M+H)+, 465 (M−H)−.

Sources & evidence

ORD record
ord-5391f91f6a104747a3df5e4f5137d13a
Source dataset
uspto-grants-2007_07
Patent number
US07238714B2

Linked notes

Loading…