5-Bromo-2,4-difluorobenzenesulfonamide → HCID 67001101, compound
Reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:13]=[C:12]([CH:14]3[CH2:16][CH2:15]3)[N:11]3[N:17]=[CH:18][C:19]([C:20]#[CH:21])=[C:10]3[N:9]=2)=[CH:4][CH:3]=1.Br[C:23]1[C:24]([F:34])=[CH:25][C:26]([F:33])=[C:27]([S:29]([NH2:32])(=[O:31])=[O:30])[CH:28]=1>>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:13]=[C:12]([CH:14]3[CH2:16][CH2:15]3)[N:11]3[N:17]=[CH:18][C:19]([C:20]#[C:21][C:23]4[C:24]([F:34])=[CH:25][C:26]([F:33])=[C:27]([S:29]([NH2:32])(=[O:30])=[O:31])[CH:28]=4)=[C:10]3[N:9]=2)=[CH:4][CH:3]=1Participants
3
Procedure
The title compound was prepared from 5-(4-chloro-phenyl)-7-cyclopropyl-3-ethynyl-pyrazolo[1,5-a]pyrimidine (example C.5) (73 mg, 0.25 mmol) and 5-bromo-2,4-difluoro-benzenesulfonamide (68 mg, 0.25 mmol) according to general procedure II. Obtained as a yellow solid (91 mg, 75%). MS (ISP) 485.1 [(M+H)+]; mp 272–275° C.
Sources & evidence
- ORD record
- ord-101677c91b034d3484917a3c12ce1edf
- Source dataset
- uspto-grants-2007_07