3-Isoxazolamine → [1-(5-tert-Butyl-isoxazol-3-ylcarbamoyl)-ethyl]-carbamic acid tert-butyl ester

HRID 1294826

Reaction equation

[C:1]([O:5][C:6](=[O:24])[NH:7][CH:8]([C:12](=[O:23])[NH:13][C:14]1[CH:18]=[C:17]([C:19]([CH3:22])([CH3:21])[CH3:20])[O:16][N:15]=1)[CH2:9]CC)([CH3:4])([CH3:3])[CH3:2].NC1C=CON=1>>[C:1]([O:5][C:6](=[O:24])[NH:7][CH:8]([C:12](=[O:23])[NH:13][C:14]1[CH:18]=[C:17]([C:19]([CH3:22])([CH3:21])[CH3:20])[O:16][N:15]=1)[CH3:9])([CH3:3])([CH3:2])[CH3:4]

Participants

Reactant 2

HCID 18102163-Isoxazolamine

HCID 69419406[1-(5-Tert-butyl-isoxazol-3-ylcarbamoyl)butyl]-carbamic acid tert-butyl ester

Product 1

HCID 69424288[1-(5-tert-Butyl-isoxazol-3-ylcarbamoyl)-ethyl]-carbamic acid tert-butyl ester

Procedure

Prepared by the analogous method for the preparation of [1-(5-tert-butyl-isoxazol-3-ylcarbamoyl)butyl]-carbamic acid tert-butyl ester, starting with an appropriate amino-isoxazole (1a-b) together with an appropriate N-t-BOC-amino acid methyl or ethyl ester.

Sources & evidence

ORD record: ord-9694e71e1dbf485283421246a81b7d07
Source dataset: uspto-grants-2007_07
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07241786B2

Linked notes

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