Methanol → Methyl 8-aminooctanoate hydrochloride

HRID 129654

Reaction equation

HRID 129654 reaction equation
S(Cl)([Cl:3])=O.[NH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][C:13]([OH:15])=[O:14].[CH3:16]O>>[ClH:3].[NH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][C:13]([O:15][CH3:16])=[O:14]

Participants

4

Reactant 3

HCID 887MethanolHCID 24386Thionyl ChlorideHCID 660858-Aminooctanoic acid

Product 1

HCID 12878164Methyl 8-aminooctanoate hydrochloride

Conditions

Temperature
20 °C

Procedure

0.7 cm3 of thionyl chloride is added to a solution of 1 g of 8-aminooctanoic acid in 40 cm3 of methanol at a temperature in the region of -20° C. and stirring is maintained for 12 hours at a temperature in the region of 20° C. The solvent is removed under reduced pressure (2.7 kPa) at a temperature in the region of 35° C. 1.48 g of methyl 8-aminooctanoate hydrochloride is thus obtained in the form of a white solid.

Workup

  1. customThe solvent is removed under reduced pressure (2.7 kPa) at a temperature in the region of 35° C

Sources & evidence

ORD record
ord-678f33cd827b41fe9bb0c6f946066656
Source dataset
uspto-grants-1995_11
Patent number
US05468888

Linked notes

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