Adenine → 9-(Phenylmethyl)-9H-purin-6-amine

Participants

Reaction Conditions

Reaction Steps

To a suspension of adenine (5) (5.00 g, 37.0 mmol) in dry DMF (120 mL) was added NaH (1.77 g, 44.4 mmol) at room temperature. The reaction mixture was stirred for 30 min and the resulting white suspension was warmed to 60° C. for an additional 30 min. Benzyl bromide (7.59 g, 44.4 mmol) was added and the mixture was stirred for 24 h at 60° C. TLC of the reaction mixture indicated the formation of two products. DMF was distilled off under reduced pressure and the resulting residue was treated with water (20 mL). The white solid that separated out, was filtered and dried under vacuum. Separation and purification was through flash column chromatography using CHCl3::MeOH (9:1) for elution. 9-Benzyladenine: yield 5.5 g. (66%); mp 231-232° C.; 1H NMR (DMSO-d6,: δ 5.38 (s, 2H, CH2), 7.29-7.33 (m, 7H, Ar—H and NH2), 8.17 (s, 1H, purine C8—H), 8.28 (s, 1H, purine C2—H). 7-Benzyladenine: yield 1.8 g. (21%). Mp 252-255° C. 1H NMR (DMSO-d6): δ 5.53 (s, 2H, CH2), 7.29-7.48 (m, 5H, Ar—H), 7.81 (s, 1H, purine C8—H), 8.0-8.1 (br, 2H, NH2), 8.6 (s, 1H, purine C2—H).

Provenance & Evidence