Hexahydro-1,4-diazepine → 1-{2-[Bis-(4-fluoro-phenyl)-methoxy]-ethyl}-[1,4]diazepane

HRID 129738

Reaction equation

HRID 129738 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]([C:13]2[CH:18]=[CH:17][C:16]([F:19])=[CH:15][CH:14]=2)[O:9][CH2:10][CH2:11]Cl)=[CH:4][CH:3]=1.[NH:20]1[CH2:26][CH2:25][CH2:24][NH:23][CH2:22][CH2:21]1>>[F:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]([C:13]2[CH:18]=[CH:17][C:16]([F:19])=[CH:15][CH:14]=2)[O:9][CH2:10][CH2:11][N:20]2[CH2:26][CH2:25][CH2:24][NH:23][CH2:22][CH2:21]2)=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 68163Hexahydro-1,4-diazepineHCID 107793021-[Bis(4-fluorophenyl)methoxy]-2-chloroethane

Product 1

HCID 106175731-{2-[Bis-(4-fluoro-phenyl)-methoxy]-ethyl}-[1,4]diazepaneYield 88%

Procedure

Following a procedure similar to that described in Preparation 1, but using 2-[bis(4-fluorophenyl)methoxy]ethyl chloride and homopiperazine, the title compound was obtained in a yield of 88%.

Workup

  1. customthat described in Preparation 1

Sources & evidence

ORD record
ord-1904ea0342004963a8abe8e3efd216a2
Source dataset
uspto-grants-1995_11
Patent number
US05470851

Linked notes

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