3-Formyl-2-methylindole → 6-methoxy-1-methyl-3-(methylaminomethyl)-1H-indole

HRID 1297432

Reaction equation

HRID 1297432 reaction equation
[CH3:1][O:2][C:3]1[CH:11]=[C:10]2[C:6]([C:7]([CH:13]=O)=[CH:8][N:9]2[CH3:12])=[CH:5][CH:4]=1.C[C:16]1[NH:17]C2C(C=1C=O)=CC=CC=2>>[CH3:1][O:2][C:3]1[CH:11]=[C:10]2[C:6]([C:7]([CH2:13][NH:17][CH3:16])=[CH:8][N:9]2[CH3:12])=[CH:5][CH:4]=1

Participants

3

Reactant 2

HCID 731663-Formyl-2-methylindoleHCID 13820106-Methoxy-1-methyl-1H-indole-3-carbaldehyde

Product 1

HCID 221391176-methoxy-1-methyl-3-(methylaminomethyl)-1H-indoleYield 87%

Procedure

According to the procedure of Preparation 12, except substituting 6-methoxy-1-methyl-1H-indole-3-carboxaldehyde for the 2-methylindole-3-carboxaldehyde, the title compound (2.1 g, 87%) was obtained as an oil: MS (ES) m/e 205.2 (M+H)+.

Workup

  1. customAccording to the procedure of Preparation 12

Sources & evidence

ORD record
ord-aab598fd85bb4c65aeef6a423e94defd
Source dataset
uspto-grants-2007_07
Patent number
US07250424B2

Linked notes

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