Water → 4,4'-Difluorobenzophenone

HRID 1303

Reaction equation

HRID 1303 reaction equation
[CH:1]1[C:6]([CH2:7][C:8]2[CH:13]=[CH:12][C:11]([F:14])=[CH:10][CH:9]=2)=[CH:5][CH:4]=[C:3]([F:15])[CH:2]=1.[OH2:16]>O=[Mn]=O>[F:15][C:3]1[CH:2]=[CH:1][C:6]([C:7]([C:8]2[CH:13]=[CH:12][C:11]([F:14])=[CH:10][CH:9]=2)=[O:16])=[CH:5][CH:4]=1

Participants

4

Reactant 2

HCID 962WaterHCID 960941,1'-Methylenebis[4-fluorobenzene]

Product 1

HCID 95824,4'-DifluorobenzophenoneYield 95%

Reagents, catalysts & solvents 1

HCID 14801Manganese dioxideCatalyst

Procedure

The procedure of Example 1 was used except that 20 g 4,4'-difluorodiphenylmethane, 30 g water, 31 g MnO2 and 50 g H2 SO4 were used. 20 g off-white solids, after toluene removal, afforded 95% pure 4,4'-difluorobenzophenone in a 90% yield.

Workup

  1. custom20 g off-white solids, after toluene removal

Sources & evidence

ORD record
ord-f59502531b224cbdb38244051ab9c738
Source dataset
uspto-grants-1998_03
Patent number
US05723676

Linked notes

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