Sulfuric Acid → 4,4'-Difluorobenzophenone
Reaction equation
[CH:1]1[C:6]([CH2:7][C:8]2[CH:13]=[CH:12][C:11]([F:14])=[CH:10][CH:9]=2)=[CH:5][CH:4]=[C:3]([F:15])[CH:2]=1.S(=O)(=O)(O)[OH:17]>O=[Mn]=O.O>[F:15][C:3]1[CH:2]=[CH:1][C:6]([C:7]([C:8]2[CH:13]=[CH:12][C:11]([F:14])=[CH:10][CH:9]=2)=[O:17])=[CH:5][CH:4]=1Participants
5
Reactant 2
Product 1
Reagents, catalysts & solvents 2
Procedure
The procedure of Example 2 is used except that the 4,4'-difluorodiphenylmethane, water, and sulfuric acid are first mixed, then heated before the MnO2 is added. The yield is 54% 4,4'-difluorobenzophenone that is 95% pure.
Workup
- additionare first mixed
- additionis added
Sources & evidence
- ORD record
- ord-dcc5f15a2f3f46578b2a4b1538a1f0d4
- Source dataset
- uspto-grants-1998_03
- Patent number
- US05723676
Reaction notes
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