Sulfuric Acid → 4,4'-Difluorobenzophenone

HRID 1304

Reaction equation

HRID 1304 reaction equation
[CH:1]1[C:6]([CH2:7][C:8]2[CH:13]=[CH:12][C:11]([F:14])=[CH:10][CH:9]=2)=[CH:5][CH:4]=[C:3]([F:15])[CH:2]=1.S(=O)(=O)(O)[OH:17]>O=[Mn]=O.O>[F:15][C:3]1[CH:2]=[CH:1][C:6]([C:7]([C:8]2[CH:13]=[CH:12][C:11]([F:14])=[CH:10][CH:9]=2)=[O:17])=[CH:5][CH:4]=1

Participants

5

Reactant 2

HCID 1118Sulfuric AcidHCID 960941,1'-Methylenebis[4-fluorobenzene]

Product 1

HCID 95824,4'-DifluorobenzophenoneYield 54%

Reagents, catalysts & solvents 2

HCID 14801Manganese dioxideCatalystHCID 962WaterSolvent

Procedure

The procedure of Example 2 is used except that the 4,4'-difluorodiphenylmethane, water, and sulfuric acid are first mixed, then heated before the MnO2 is added. The yield is 54% 4,4'-difluorobenzophenone that is 95% pure.

Workup

  1. additionare first mixed
  2. additionis added

Sources & evidence

ORD record
ord-dcc5f15a2f3f46578b2a4b1538a1f0d4
Source dataset
uspto-grants-1998_03
Patent number
US05723676

Linked notes

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