3-Phenoxy-1,2-propanediol → Phenoxyacetaldehyde

HRID 13077

Reaction equation

HRID 13077 reaction equation
I([O-])(=O)(=O)=O.[Na+].[O:7]([CH2:14][CH:15]([OH:18])CO)[C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1>ClCCl>[O:7]([CH2:14][CH:15]=[O:18])[C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1

Participants

4

Reactant 2

HCID 108573-Phenoxy-1,2-propanediolHCID 23667635Sodium periodate

Product 1

HCID 75033PhenoxyacetaldehydeYield 100%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent2×

Procedure

Sodium periodate (0.65 M in water, 20 mL) was added to a vigorously stirred suspension of silica gel (20 g) in dichloromethane (160 mL), followed by a solution of 3-phenoxy-1,2-propanediol (1.68 g, 10.0 mmol) in dichloromethane (20 mL). After stirring for 10 min the mixture was filtered and the filtrate was concentrated to give the subtitle compound (1.36 g, 100%).

Workup

  1. filtrationwas filtered
  2. concentrationthe filtrate was concentrated

Sources & evidence

ORD record
ord-1e1e15121926420891672153556960f2
Source dataset
uspto-grants-2010_06
Patent number
US07728030B2

Linked notes

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