(S)-2-((tert)-Butoxycarbonyl)amino)butanoic acid → (S)-2-(Boc-Amino)-N-methoxy-n-methylbutyramide

Reaction equation

[CH3:1][O:2][N:3]([CH3:18])[C:4](=[O:17])[C@@H:5]([NH:9][C:10](=[O:16])[O:11][C:12]([CH3:15])([CH3:14])[CH3:13])[CH2:6][CH2:7]C.C(OC(N[C@@H](CC)C(O)=O)=O)(C)(C)C>>[CH3:1][O:2][N:3]([CH3:18])[C:4](=[O:17])[C@@H:5]([NH:9][C:10](=[O:16])[O:11][C:12]([CH3:13])([CH3:15])[CH3:14])[CH2:6][CH3:7]

Participants

Reactant 2

HCID 2755934(S)-2-((tert)-Butoxycarbonyl)amino)butanoic acid

HCID 9992774(S)-tert-butyl 1-(methoxy(methyl)amino)-1-oxopentan-2-ylcarbamate

Product 1

HCID 10422029(S)-2-(Boc-Amino)-N-methoxy-n-methylbutyramide

Procedure

was synthesised in the same way as (91d) from commercially available (2S)-2-[(tert-butoxycarbonyl)amino]butanoic acid (0.935 g, 4.60 mmol).

Sources & evidence

ORD record: ord-9d9db886bc5e4421b3043558471c1a63
Source dataset: uspto-grants-2010_06
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07728030B2

Reaction notes

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