(S)-2-(Boc-Amino)-N-methoxy-n-methylbutyramide → (S)-tert-butyl 1-(3-methoxyphenyl)-1-oxobutan-2-ylcarbamate

HRID 13116Notes

Reaction equation

HRID 13116 reaction equation
[O:1]=[C:2]([C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1)[C@@H:3]([NH:7][C:8](=[O:14])[O:9][C:10]([CH3:13])([CH3:12])[CH3:11])[CH2:4][CH2:5]C.[CH3:21][O:22]N(C)C(=O)[C@@H](NC(=O)OC(C)(C)C)CC>>[CH3:21][O:22][C:19]1[CH:20]=[C:15]([C:2](=[O:1])[C@@H:3]([NH:7][C:8](=[O:14])[O:9][C:10]([CH3:11])([CH3:12])[CH3:13])[CH2:4][CH3:5])[CH:16]=[CH:17][CH:18]=1

Participants

3

Reactant 2

HCID 10422029(S)-2-(Boc-Amino)-N-methoxy-n-methylbutyramideHCID 59339674(S)-tert-butyl 1-oxo-1-phenylpentan-2-ylcarbamate

Product 1

HCID 59339726(S)-tert-butyl 1-(3-methoxyphenyl)-1-oxobutan-2-ylcarbamate

Procedure

was synthesised in the same way as 91c from (S)-tert-butyl 1-(methoxy(methyl)amino)-1-oxobutan-2-ylcarbamate (95d, 250 mg, 1.02 mmol).

Sources & evidence

ORD record
ord-cf9207226855441884d1f9f9c05987c1
Source dataset
uspto-grants-2010_06
Patent number
US07728030B2

Reaction notes

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