(S)-2-(Piperazin-2-yl)ethanol → (S)-7-Chloro-10-[3-(2-hydroxy-ethyl)-piperazin-1-yl]-2-methyl-4H-3-thia-4,9-diaza-benzo[f]azulene
Reaction equation
Cl.[Cl:2][C:3]1[CH:18]=[CH:17][C:6]2[NH:7][C:8]3[S:9][C:10]([CH3:16])=[CH:11][C:12]=3[C:13]([NH2:15])=[N:14][C:5]=2[CH:4]=1.[OH:19][CH2:20][CH2:21][C@H:22]1[CH2:27]N[CH2:25][CH2:24][NH:23]1>>[Cl:2][C:3]1[CH:18]=[CH:17][C:6]2[NH:7][C:8]3[S:9][C:10]([CH3:16])=[CH:11][C:12]=3[C:13]([N:15]3[CH2:25][CH2:24][NH:23][C@@H:22]([CH2:21][CH2:20][OH:19])[CH2:27]3)=[N:14][C:5]=2[CH:4]=1Participants
3
Procedure
By using a method similar to Example 258, using 7-chloro-2-methyl-4H-3-thia-4,9-diaza-benzo[f]azulen-10-ylamine hydrochloride and (S)-2-(2-hydroxy-ethyl)-piperazine gives the title compound.
Sources & evidence
- ORD record
- ord-a4cd8fdb63dc4c6b9aa53bff7f2f89a4
- Source dataset
- uspto-grants-2008_06