HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Aminothiazole → 2-(3-Methoxy-2-methoxycarbonylphenoxy)-1-nitrobenzene
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Aminothiazole | HCID 2155 | — |
| Reactant | 1-Fluoro-2-nitrobenzene | HCID 73895 | — |
| Reactant | Methyl 2-hydroxy-6-methoxybenzoate | HCID 527092 | — |
| Reactant | 2-(3-Methoxy-2-methoxycarbonylphenoxy)aniline | HCID 66998871 | — |
| Product | N-[(3-methoxy-2-methoxycarbonylphenoxy)phenyl]-N'-(thiazol-2-yl)urea | HCID 59732821 | 65% |
| Product | 2-(3-Methoxy-2-methoxycarbonylphenoxy)-1-nitrobenzene | HCID 66998834 | 80% |
Reaction Steps
2-(3-Methoxy-2-methoxycarbonylphenoxy)-1-nitrobenzene (1.21 g, 80%) was prepared from methyl 6-methoxysalicylate (1.09 g, 5.5 mmol) and 1-fluoro-2-nitrobenzene (0.71 g, 5.0 mmol) following the general procedure A. This compound was reduced to 2-(3-methoxy-2-methoxycarbonylphenoxy)aniline (0.82 g, 75%) following the general procedure C. N-[(3-methoxy-2-methoxycarbonylphenoxy)phenyl]-N′-(thiazol-2-yl)urea (130 mg, 65%) was prepared from 2-(3-methoxy-2-methoxycarbonylphenoxy)aniline (136 mg, 0.5 mmol) and 2-aminothiazole (60 mg, 0.6 mmol) following the general procedure D.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07384967B2 |
| Source dataset | uspto-grants-2008_06 |
| ORD ID | ord-bfe7f4fbb7684d10bb8c292a558af4b0 |
| Source note | uspto-grants-2008_06 |