Methyl 3-mercaptopropionate → HCID 43617626, compound

HRID 131898

Reaction equation

HRID 131898 reaction equation
Cl[CH2:2][C:3]1[N:4]=[C:5]([NH2:8])[S:6][CH:7]=1.[CH3:9][O:10][C:11](=[O:15])[CH2:12][CH2:13][SH:14]>>[CH3:9][O:10][C:11](=[O:15])[CH2:12][CH2:13][S:14][CH2:2][C:3]1[N:4]=[C:5]([NH2:8])[S:6][CH:7]=1

Participants

3

Reactant 2

HCID 18050Methyl 3-mercaptopropionateHCID 732294-Chloromethylthiazol-2-ylamine

Product 1

HCID 43617626HCID 43617626, compoundYield 60%

Procedure

3-(2-Amino-thiazol-4-ylmethylsulfanyl)-propionic acid methyl ester (0.75 g, 60%) was prepared from 4-chloromethyl-thiazol-2-ylamine (1.00 g, 5.41 mmol) and 3-mercapto-propionic acid methyl ester (0.97 g, 8.11 mmol) according to procedure Z.

Sources & evidence

ORD record
ord-0a65a01ed6e8487db7b8cbbd99ffa4af
Source dataset
uspto-grants-2008_06
Patent number
US07384967B2

Linked notes

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