Benzo(b)thiophene-2-carboxylic acid → HCID 59339811, compound

HRID 13209

Reaction equation

HRID 13209 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([N:8]2[C:16]3[C:11](=[CH:12][C:13]([O:17][C@H:18]([C:22]4[CH:27]=[CH:26][CH:25]=[C:24]([O:28][CH3:29])[CH:23]=4)[C@@H:19]([NH2:21])[CH3:20])=[CH:14][CH:15]=3)[CH:10]=[N:9]2)=[CH:4][CH:3]=1.[S:30]1[C:34]([C:35](O)=[O:36])=[CH:33][C:32]2[CH:38]=[CH:39][CH:40]=[CH:41][C:31]1=2>>[F:1][C:2]1[CH:3]=[CH:4][C:5]([N:8]2[C:16]3[C:11](=[CH:12][C:13]([O:17][C@H:18]([C:22]4[CH:27]=[CH:26][CH:25]=[C:24]([O:28][CH3:29])[CH:23]=4)[C@@H:19]([NH:21][C:35]([C:34]4[S:30][C:31]5[CH:41]=[CH:40][CH:39]=[CH:38][C:32]=5[CH:33]=4)=[O:36])[CH3:20])=[CH:14][CH:15]=3)[CH:10]=[N:9]2)=[CH:6][CH:7]=1

Participants

3

Reactant 2

HCID 95864Benzo(b)thiophene-2-carboxylic acidHCID 59339733(1R,2S)-1-(1-(4-fluorophenyl)indazol-5-yloxy)-1-(3-methoxyphenyl)propan-2-amine

Product 1

HCID 59339811HCID 59339811, compound

Procedure

Prepared as described in Example 269 from (1R,2S)-1-(1-(4-fluorophenyl)-1H-indazol-5-yloxy)-1-(3-methoxyphenyl)propan-2-amine (6a, 50 mg, 0.13 mmol) and benzo[b]thiophene-2-carboxylic acid (27 mg, 0.15 mmol).

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-ec08d3dd699943c5b6043fb86420e555
Source dataset
uspto-grants-2010_06
Patent number
US07728030B2

Linked notes

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