HCID 60131304, compound → (S,S)-2-Amino-3-cyclohexyl-N-[1-methyl-2-(4-trifluoromethoxy-phenylamino)-ethyl]-propionamide
Reaction equation
C(OC(=O)[NH:10][C@H:11]([C:19](=[O:36])[NH:20][C@@H:21]([CH3:35])[CH2:22][NH:23][C:24]1[CH:29]=[CH:28][C:27]([O:30][C:31]([F:34])([F:33])[F:32])=[CH:26][CH:25]=1)[CH2:12][CH:13]1[CH2:18][CH2:17][CH2:16][CH2:15][CH2:14]1)C1C=CC=CC=1>[Pd].CO>[NH2:10][C@@H:11]([CH2:12][CH:13]1[CH2:14][CH2:15][CH2:16][CH2:17][CH2:18]1)[C:19]([NH:20][C@@H:21]([CH3:35])[CH2:22][NH:23][C:24]1[CH:29]=[CH:28][C:27]([O:30][C:31]([F:32])([F:33])[F:34])=[CH:26][CH:25]=1)=[O:36]Participants
4
Reactant 1
Product 1
Reagents, catalysts & solvents 2
Procedure
The product from step C (138 mg, 0.265 mmol) and 5 mol % of 10% palladium on carbon (14 mg) was dissolved in 20 mL of methanol and purged with nitrogen. Balloon pressure of hydrogen was added and the resulting slurry was stirred for 5 hours. The septum was removed and the slurry was filtered through celite and concentrated. Yield 98 mg, quantitative.