Formic Acid → Epichlorohydrin dimethylaminopropylamine benzylamine

Participants

Reaction Conditions

Reaction Steps

1 020 g (10 mol) of dimethylaminopropylamine and 267.5 g (2.5 mol) of benzylamine are mixed in 1 519.1 g of water. The solution/suspension is heated to 50° C. Thereafter, 931 ml of epichlorohydrin (1 098.4 g/l 1.875 mol) are added dropwise at a rate of 16 ml/min while heating to 85° C., and stirring is effected for two hours at 85° C. The stirring at 85° C. is continued until free alkylating agent is no longer detectable (Preuβmann test). The reaction mixture is cooled, diluted with 2 l of water and brought to a pH of 7.0 with 85% strength formic acid. Further water is added until the solids content is 21%.

Provenance & Evidence