HuagongsheHuagongshe Chemistry Print Report · For research reference only
5-Aminophthalide → 5-[3-[1-{2-Fluoro-3-trifluoromethylphenyl)-cyclopropyl]-2-oxo-propionylamino}-phthalide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 5-Aminophthalide | HCID 720669 | — |
| Reactant | 3-[1-(2-Fluoro-3-trifluoromethylphenyl)-cyclopropyl]-2-oxo-propionic acid | HCID 69303957 | — |
| Product | 5-[3-[1-{2-Fluoro-3-trifluoromethylphenyl)-cyclopropyl]-2-oxo-propionylamino}-phthalide | HCID 69303614 | — |
Reaction Steps
Preparation from 3-[1-(2-fluoro-3-trifluoromethylphenyl)-cyclopropyl]-2-oxo-propionic acid and 5-aminophthalide analogously to the preparation of 5-{3-[1-(2-fluoro-5-trifluoromethylphenyl)-cyclopropyl]-2-oxo-propionylamino}-phthalide (cf. Example 1a)). M.p. 157-158° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07388006B2 |
| Source dataset | uspto-grants-2008_06 |
| ORD ID | ord-d54ecfbcb7874a0dbf0b69b2c808a283 |
| Source note | uspto-grants-2008_06 |