1-methyl-1H-pyrazole-3-carboxylic acid → 5-(2,4-Difluoro-phenoxy)-2-(1-methyl-1H-pyrazol-3-yl)-6-(6-ethanesulfonyl-pyridin-3-yloxy)-1H-benzimidazole

HRID 13314

Reaction equation

HRID 13314 reaction equation
[F:1][C:2]1[CH:35]=[C:34]([F:36])[CH:33]=[CH:32][C:3]=1[O:4][C:5]1[C:19]([O:20][C:21]2[CH:22]=[N:23][C:24]([S:27]([CH2:30][CH3:31])(=[O:29])=[O:28])=[CH:25][CH:26]=2)=[CH:18][C:8]2[NH:9][C:10]([C:12]3[CH:17]=[CH:16]C=CN=3)=[N:11][C:7]=2[CH:6]=1.[CH3:37][N:38]1C=CC(C(O)=O)=[N:39]1>>[F:1][C:2]1[CH:35]=[C:34]([F:36])[CH:33]=[CH:32][C:3]=1[O:4][C:5]1[C:19]([O:20][C:21]2[CH:22]=[N:23][C:24]([S:27]([CH2:30][CH3:31])(=[O:28])=[O:29])=[CH:25][CH:26]=2)=[CH:18][C:8]2[NH:9][C:10]([C:12]3[CH:17]=[CH:16][N:38]([CH3:37])[N:39]=3)=[N:11][C:7]=2[CH:6]=1

Participants

3

Reactant 2

HCID 5731761-methyl-1H-pyrazole-3-carboxylic acidHCID 231452495-(2,4-Difluoro-phenoxy)-2-pyridin-2-yl-6-(6-ethanesulfonyl-pyridin-3-yloxy)-1H-benzimidazole

Product 1

HCID 1356979885-(2,4-Difluoro-phenoxy)-2-(1-methyl-1H-pyrazol-3-yl)-6-(6-ethanesulfonyl-pyridin-3-yloxy)-1H-benzimidazole

Procedure

The entitled compound was obtained as a colorless solid in the same method as in Example 203 or in accordance with the method or by combining it with an ordinary method but using 4-(2,4-difluoro-phenoxy)-5-(6-ethanesulfonyl-pyridin-3-yloxy)-benzene-1,2-diamine obtained in Example 229 and 1-methyl-1H-pyrazole-3-carboxylic acid.

Workup

  1. customThe entitled compound was obtained as a colorless solid in the same method as in Example 203 or in accordance with the method

Sources & evidence

ORD record
ord-b35ce76bb3254f7e9b6704664e3eedb4
Source dataset
uspto-grants-2010_06
Patent number
US07728025B2

Linked notes

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