HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 13326Generated: October 27, 2026
Dimethylformamide → N-(4-benzyloxy-5-(2-fluorophenoxy)-2-nitrophenyl)pyrazinecarboxamide
https://huagongshe.com/reaction/13326
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Dimethylformamide | HCID 6228 | — |
| Reactant | 2-Fluorophenol | HCID 9707 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | N-(4-benzyloxy-5-fluoro-2-nitrophenyl)pyrazinecarboxamide | HCID 23145743 | — |
| Solvent | Water | HCID 962 | — |
| Product | N-(4-benzyloxy-5-(2-fluorophenoxy)-2-nitrophenyl)pyrazinecarboxamide | HCID 23145658 | — |
Reaction Steps
0.54 ml of 2-fluorophenol and 2.53 g of potassium carbonate were added to a dimethylformamide (16 ml) solution of 2.14 g of N-(4-benzyloxy-5-fluoro-2-nitrophenyl)pyrazinecarboxamide, and the reaction liquid was stirred at 90° C. for 5 hours, and then water was added to it. The resulting deposit was taken out through filtration to obtain the entitled compound as a yellow solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US07728025B2 |
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| Source dataset | uspto-grants-2010_06 |
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| ORD ID | ord-76da9412acef46d08b316ba9c7c4c87c |
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| Source note | uspto-grants-2010_06 |
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