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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 13337Generated: October 26, 2026

1-Methyl-3-hydroxypyridine-2-one → 5-(1-Methyl-2-oxo-1,2-dihydro-pyridin-3-yloxy)-6-(4-methanesulfonyl-phenoxy)-2-pyridin-2-yl-1H-benzimidazole

https://huagongshe.com/reaction/13337

Reaction equation

Participants

RoleNameHCIDCharge
Reactant1-Methyl-3-hydroxypyridine-2-oneHCID 88026—
Reactant5-(2-Ethoxycarbonyl-phenoxy)-6-(4-methanesulfonyl-phenoxy)-2-pyridin-2-yl-1H-benzimidazoleHCID 23145140—
Product5-(1-Methyl-2-oxo-1,2-dihydro-pyridin-3-yloxy)-6-(4-methanesulfonyl-phenoxy)-2-pyridin-2-yl-1H-benzimidazoleHCID 23145395—

Reaction Steps

The entitled compound was obtained as a brown solid in the same method as in Example 14 or in accordance with the method or by combining it with an ordinary method but using 5-fluoro-4-(4-methanesulfonyl-phenoxy)-2-nitro-phenylamine obtained in Example 14 and 1-methyl-2-oxo-1,2-dihydro-pyridin-3-ol.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07728025B2
Source datasetuspto-grants-2010_06
ORD IDord-3b99a0b0c8f64e1e85c662db1bbbab56
Source noteuspto-grants-2010_06